abstract：:A study was made of the effects of taurine on GABArho1 receptors expressed in Xenopus oocytes. The EC(50) and reversal potentials for GABA, taurine and glycine currents were 2.3+/-0.4 microM (-25+/-0.9 mV), 5+/-0.8mM (-27+/-0.4 mV) and 7+/-0.5mM (-22+/-0.6 mV), respectively. Co-application of GABA and taurine, reveale...

journal_title：Neuroscience research

authors： Ochoa-de la Paz LD,Martínez-Dávila IA,Miledi R,Martínez-Torres A

更新日期：2008-07-01 00:00:00

abstract：:We used functional magnetic resonance imaging in 18 normal volunteers to determine whether there is separate representation of syntactic, semantic, and verbal working memory processing in the left inferior frontal gyrus (GFi). We compared a sentence comprehension task with a short-term memory maintenance task to ident...

journal_title：Neuroscience research

authors： Uchiyama Y,Toyoda H,Honda M,Yoshida H,Kochiyama T,Ebe K,Sadato N

更新日期：2008-07-01 00:00:00

abstract：:The 14-3-3 protein family consists of evolutionarily conserved, acidic 30 kDa proteins composed of seven isoforms named beta, gamma, epsilon, zeta, eta, theta, and sigma in mammalian cells. The dimeric complex of 14-3-3 isoforms, acting as a molecular adaptor, plays a central role in regulation of neuronal function. S...

journal_title：Neuroscience research

authors： Tabunoki H,Shimada T,Banno Y,Sato R,Kajiwara H,Mita K,Satoh J

更新日期：2008-07-01 00:00:00

abstract：:We studied hippocampal cellular proliferation and neurogenesis processes in a model of transient global cerebral ischemia in gerbils by labelling dividing cells with 5'-Bromo-2'-deoxyuridine (BrdU). Surrounding the region of selective neuronal death (CA1 pyramidal layer of the hippocampus), an important increase in re...

journal_title：Neuroscience research

authors： Salazar-Colocho P,Lanciego JL,Del Rio J,Frechilla D

更新日期：2008-05-01 00:00:00

abstract：:We carried out voltage-sensitive dye imaging of the guinea pig auditory cortex to determine whether the ongoing and spontaneous activities of the cortex exhibit spatial coherence reflecting the tonotopic organization of the cortex. We used independent component analysis and a signal-plus-noise model to extract ongoing...

journal_title：Neuroscience research

authors： Yoshida T,Sakagami M,Katura T,Yamazaki K,Tanaka S,Iwamoto M,Tanaka N

更新日期：2008-05-01 00:00:00

abstract：:Stroke is a common cause of death and severe disability among adults in developed countries. Cigarette smoking adversely affects human health in many ways and is considered to be a risk factor for a stroke. However, the mechanism that determines the relative importance of neurotrophins in this process remains unclear....

journal_title：Neuroscience research

authors： Yang JT,Chang CN,Wu JH,Chung CY,Weng HH,Cheng WC,Lee TH

更新日期：2008-04-01 00:00:00

abstract：:Recently, we reported a profound depletion of cardiac sympathetic nerve fibers in Parkinson's disease (PD). This cardiac sympathetic denervation is a characteristic hallmark of PD. Cardiac sympathetic dysfunction was also observed in 1-methyl-4-phenyl-1,2,3,6-tetrahydroxypyridine (MPTP)-treated mice, a model of PD. Al...

journal_title：Neuroscience research

authors： Amino T,Uchihara T,Tsunekawa H,Takahata K,Shimazu S,Mizusawa H,Orimo S

更新日期：2008-03-01 00:00:00

abstract：:Angiotensin II (Ang II) receptors are located in different regions of the brain, particularly within the cardiovascular control centers in the brainstem. These Ang II receptors are divided into AT1 and AT2 subtypes. We investigated the role of AT1 receptor subtype within the rostral (RVLM) and caudal (CVLM) ventrolate...

journal_title：Neuroscience research

authors： Patel D,Böhlke M,Phattanarudee S,Kabadi S,Maher TJ,Ally A

更新日期：2008-03-01 00:00:00

abstract：:The aim of this study was to investigate the differences between children and adults in recognizing facial expressions of simple line drawings of "Chernoff's face". First, the angles of the eyebrows and mouth of Chernoff's face were changed in a stepwise way with a personal computer, and the emotional response of the ...

journal_title：Neuroscience research

authors： Tsurusawa R,Goto Y,Mitsudome A,Nakashima T,Tobimatsu S

更新日期：2008-02-01 00:00:00

abstract：:In identified B6 neurons of Aplysia buccal ganglia under voltage-clamp, application of quisqualic acid (QA) induces a unique slow K(+)-current response independent of G-protein. The response was augmented by raising the temperature in a similar fashion to the Phe-Met-Arg-Phe-NH(2)-induced K(+)-current response mediate...

journal_title：Neuroscience research

authors： Kimura S,Kawasaki S,Watanabe S,Fujita R,Sasaki K

更新日期：2008-01-01 00:00:00

abstract：:In our previous study using the whole-cell patch clamp technique combined with reverse transcription-polymerase chain reaction analysis in rat brainstem slices, we demonstrated that the classification of neurons in the medial vestibular nucleus (MVN) based on three membrane properties detected as voltage response prop...

journal_title：Neuroscience research

authors： Saito Y,Ozawa S

更新日期：2007-10-01 00:00:00

abstract：:In the past few years, the plasticity of the regional specification of the CNS has been widely debated on the results from in utero transplantation. Two different results are reported with this transplantation method. One is that the distribution of transplanted cells is dependent on the donor origin, and the other is...

journal_title：Neuroscience research

authors： Honda S,Toda K,Tozuka Y,Yasuzawa S,Iwabuchi K,Tomooka Y

更新日期：2007-10-01 00:00:00

abstract：:We have previously shown that endothelin-B receptor stimulation increases neural progenitor proliferation, partly in G(i) and extracellular matrix molecule-dependent manner. In the present study, we investigated whether G(q/11) is also involved in this response and how G(i) and G(q/11) might regulate the extracellular...

journal_title：Neuroscience research

authors： Morishita R,Ueda H,Ito H,Takasaki J,Nagata K,Asano T

更新日期：2007-10-01 00:00:00

abstract：:This study was designed to evaluate the anticonvulsant effects of imperatorin (a furanocoumarin isolated from fruits of Angelica archangelica) in the mouse maximal electroshock seizure threshold model. The threshold for electroconvulsions in mice was determined at several times: 15, 30, 60 and 120 min after i.p. admin...

journal_title：Neuroscience research

authors： Luszczki JJ,Glowniak K,Czuczwar SJ

更新日期：2007-09-01 00:00:00

abstract：:Speech prosody is considered to be one of the most important sources of information for infants in acquiring their native language. Using multi-channel near-infrared spectroscopy in 10-month-old infants, we examined cortical activation when normal and flattened speech sounds were presented to the infants. The flattene...

journal_title：Neuroscience research

authors： Homae F,Watanabe H,Nakano T,Taga G

更新日期：2007-09-01 00:00:00

abstract：:Saccadic eye movement is a rapid shift of eye position to capture an object in the environment. In this study, we will describe the fundamental properties of spontaneously evoked saccade-like rapid eye movement (SLREM) in mice in order to establish the mouse experimental model for studying saccades. Spontaneous SLREM ...

journal_title：Neuroscience research

authors： Sakatani T,Isa T

更新日期：2007-07-01 00:00:00

abstract：:Withdrawal may be a natural model to study craving and compulsive drug seeking, since craving can be viewed as a conditioned dysphoric state. It has been suggested that functional connectivity between brain areas may be of major value in explaining excessive craving and compulsive drug seeking by providing essential l...

journal_title：Neuroscience research

authors： Fingelkurts AA,Fingelkurts AA,Kivisaari R,Autti T,Borisov S,Puuskari V,Jokela O,Kähkönen S

更新日期：2007-05-01 00:00:00

abstract：:The subthalamic nucleus occupies a position in the indirect pathway of basal ganglia circuit, which plays an important role in the movement regulation. Zolpidem is an imidazopyridine agonist with a high affinity on the benzodiazepine site of GABA(A) receptors containing alpha 1 subunit. Recently, zolpidem has been rep...

journal_title：Neuroscience research

authors： Chen L,Xie JX,Fung KS,Yung WH

更新日期：2007-05-01 00:00:00

abstract：:We previously demonstrated that metabotropic glutamate receptor-subtype 1 knockout [mGluR1 (-/-)] mice showed ataxic gait, deficient long-term depression and impaired synapse elimination and these phenotypes were rescued by introduction of an mGluR1 transgene with Purkinje cell-specific promoter (mGluR1-rescue mice). ...

journal_title：Neuroscience research

authors： Nakao H,Nakao K,Kano M,Aiba A

更新日期：2007-04-01 00:00:00

abstract：:To identify the roles of VGCC subtypes in damages/impairs of inhibitory transmission during epileptogenesis, we investigated temporal- and spatial-specific alterations in voltage-gated Ca(2+) channel (VGCC) immunoreactivities within parvalbumin (PV, a Ca(2+) binding protein) positive neurons in the rat hippocampus fol...

journal_title：Neuroscience research

authors： Kim JE,Kwak SE,Kim DS,Won MH,Choi HC,Song HK,Kim YI,Kang TC

更新日期：2007-03-01 00:00:00

abstract：:Striatonigral axons co-release GABA and substance P (SP) at their target sites, but little is known about the action of SP at nigral level. Therefore, we studied immunohistochemically the cellular and subcellular localization of SP and its high affinity receptors neurokinin-1 (NK-1R) and neurokinin-3 (NK-3R) at nigral...

journal_title：Neuroscience research

authors： Lévesque M,Wallman MJ,Parent R,Sík A,Parent A

更新日期：2007-03-01 00:00:00

abstract：:Previous pharmacological experiments provide conflicting findings that describe both facilitatory and inhibitory effects of neuronal histamine on learning and memory. Here, we examined learning and memory and synaptic plasticity in mice with a null mutation of gene coding histamine H1 or H2 receptor in order to clarif...

journal_title：Neuroscience research

authors： Dai H,Kaneko K,Kato H,Fujii S,Jing Y,Xu A,Sakurai E,Kato M,Okamura N,Kuramasu A,Yanai K

更新日期：2007-02-01 00:00:00

abstract：:Recent technologies and developments in neuroscience have contributed to remarkable scientific discoveries, and have also raised many new philosophical, ethical, legal, and social issues. Research in "neuroethics" has identified various ethical issues, which will be difficult for current biomedical ethics to resolve f...

journal_title：Neuroscience research

authors： Fukushi T,Sakura O,Koizumi H

更新日期：2007-01-01 00:00:00

abstract：:The DYT1 gene containing a trinucleotide deletion (DeltaGAG) is linked to early-onset dystonia, a neurological movement disorder of involuntary muscle contractions. To understand DYT1's contribution to dystonia, we produced and analyzed Dyt1 knockdown (KD) mice that expressed a reduced level of torsinA protein encoded...

journal_title：Neuroscience research

authors： Dang MT,Yokoi F,Pence MA,Li Y

更新日期：2006-12-01 00:00:00

abstract：:Reflex blinking provides a useful experimental tool for various functional studies on the peripheral and central nervous system, yet the neuronal circuitry underlying this reflex is not precisely known. In the present study, we investigated as to whether neurons in the reticular formation and rostral cervical spinal c...

journal_title：Neuroscience research

authors： Smit AE,Buisseret P,Buisseret-Delmas C,De Zeeuw CI,VanderWerf F,Zerari-Mailly F

更新日期：2006-12-01 00:00:00

abstract：:Dopaminergic neurons of the substantia nigra pars compacta play a major role in goal-directed behavior and reinforcement learning. The study of their local interactions has revealed that they are connected by electrical synapses. Connexins, the molecular substrate of electrical synapses, constitute a multigenic family...

journal_title：Neuroscience research

authors： Vandecasteele M,Glowinski J,Venance L

更新日期：2006-12-01 00:00:00

abstract：:The actin cytoskeleton plays a critical role in the cellular morphological changes. Its organization is essential for neurite extension and synaptogenesis under the processes of neuronal development. Recently, neural Wiskott-Aldrich syndrome protein (N-WASP) and WASP family verprolin-homologous protein (WAVE) have bee...

journal_title：Neuroscience research

authors： Tsuchiya D,Kitamura Y,Takata K,Sugisaki T,Taniguchi T,Uemura K,Miki H,Takenawa T,Shimohama S

更新日期：2006-12-01 00:00:00

abstract：:Epidermal growth factor (EGF) is a well-known neurotrophic factor regulating the development of various neuronal cells, including dopaminergic neurons, and dysfunction of EGF signals has been demonstrated as a risk factor for schizophrenia. Recently, several researchers have investigated associations including age at ...

journal_title：Neuroscience research

authors： Lee KY,Ahn YM,Joo EJ,Joo YH,Chang JS,Yoo HY,Kim YS

更新日期：2006-12-01 00:00:00

abstract：:Rhotekin, an effector of Rho, is highly expressed in the brain but its function(s) in neurons is almost unknown. In an attempt to define the properties of Rhotekin in neuronal cells, we focused on its interaction with polarity-related molecules. In the present study, we identified a PDZ protein, Lin-7B, as a binding p...

journal_title：Neuroscience research

authors： Sudo K,Ito H,Iwamoto I,Morishita R,Asano T,Nagata K

更新日期：2006-12-01 00:00:00

abstract：:The N-methyl-D-aspartate (NMDA) receptor 2B gene (GRIN2B) was studied as a candidate gene of alcoholism. This study aimed to investigate the association between each of the three GRIN2B polymorphisms (rs1806201, rs1805247, and rs1805502) and alcoholism. This study included 206 alcoholic patients and 189 unrelated cont...

journal_title：Neuroscience research

authors： Kim JH,Park M,Yang SY,Jeong BS,Yoo HJ,Kim JW,Chung JH,Kim SA

更新日期：2006-10-01 00:00:00

abstract：:Transforming growth factor beta (TGF-beta) is an extracellular signaling molecule known to mediate programmed cell death (PCD) in the developing retina. In the present study, we investigated the expression profiles and activity levels of TGF-beta ligand and TGF-beta receptors (TbetaR) during the successive physiologic...

journal_title：Neuroscience research

authors： Beier M,Franke A,Paunel-Görgülü AN,Scheerer N,Dünker N

更新日期：2006-10-01 00:00:00

abstract：:Various heterotrimeric G protein betagamma subunits (Gbetagamma) are region-specifically expressed in brain where associated with "stress-axis", however, the role of Gbetagamma-mediated signaling in regulating stress is unknown. This study was designed to examine the changes of Gbetagamma expression and Gbetagamma-med...

journal_title：Neuroscience research

authors： Lee SY,Kang JS,Song GY,Myung CS

更新日期：2006-10-01 00:00:00

abstract：:A disynaptic projection from the spinal cord to the striatum was observed in the rat light and electron microscopically. An anterograde tracer, wheat germ agglutinin conjugated to horseradish peroxidase was injected into the ventral gray matter of the upper cervical spinal cord, and a retrograde tracer, biotinylated d...

journal_title：Neuroscience research

authors： Nakamura Y,Otake K,Tokuno H

更新日期：2006-09-01 00:00:00

abstract：:Visual-spatial navigation in familiar and unfamiliar environments is an essential requirement of daily life. Animal studies indicated the importance of the hippocampus for navigation. Neuroimaging studies demonstrated gender difference or strategies dependent difference of neural substrates for navigation. Using funct...

journal_title：Neuroscience research

authors： Ohnishi T,Matsuda H,Hirakata M,Ugawa Y

更新日期：2006-08-01 00:00:00

abstract：:Glutamate is the principal excitatory neurotransmitter in the mammalian central nervous system (CNS). Glutamate is first synthesized in the cytoplasm of presynaptic terminals before being loaded into synaptic vesicles, which fuse with the plasma membrane, releasing their contents, in response to neuronal activity. The...

journal_title：Neuroscience research

authors： Takamori S

更新日期：2006-08-01 00:00:00

abstract：:Afferent neurons entering the central nervous systems of vertebrates and invertebrates receive presynaptic inhibition on their axon terminals. This usually involves an increase in membrane conductance (shunting) and depolarization (primary afferent depolarization, PAD). In arachnids and crustaceans the peripherally lo...

journal_title：Neuroscience research

authors： French AS,Panek I,Torkkeli PH

更新日期：2006-06-01 00:00:00

abstract：:Mutations in the dynamin family GTPase OPA1 are reportedly the cause of autosomal dominant optic atrophy, the most frequently occurring form of hereditary optic neuropathy. But although the involvement of structural abnormalities of the enzyme in this neurodegenerative disease is clear, little is known about the cell ...

journal_title：Neuroscience research

authors： Misaka T,Murate M,Fujimoto K,Kubo Y

更新日期：2006-06-01 00:00:00

abstract：:We examined the effects of the gravitational vertical on the perception of reversible figures. Each reversible figure had two interpretations depending on whether it was viewed vertically in one orientation or upside down. When it was presented horizontally, the two interpretations alternated. Subjects were required t...

journal_title：Neuroscience research

authors： Yamamoto S,Yamamoto M

更新日期：2006-06-01 00:00:00

abstract：:Changes in synaptic efficacy at the parallel fiber (PF)-Purkinje cell (PC) synapse are postulated to be a cellular basis for motor learning. Although long-term efficacy changes lasting more than an hour at this synapse, i.e., long-term potentiation and depression, have been extensively studied, relatively short lastin...

journal_title：Neuroscience research

authors： Goto J,Inoue T,Kuruma A,Mikoshiba K

更新日期：2006-05-01 00:00:00

abstract：:NMDA receptors play an important functional role in the neuron excitability and plasticity. The conditions and consequences of their activation are of interest for many neuroscientists. This investigation was designed to explore an activation of the NMDA receptors of frog tectal neurons in vivo by a burst of spikes of...

journal_title：Neuroscience research

authors： Kuras A,Baginskas A,Batuleviciene V

更新日期：2006-04-01 00:00:00